Why does bupropion and paroxetine say severe interaction. I've been on these two for years and when I saw the severe interaction I was alarmed. When I told my doctor, she said she looked it up and it is not severe. I want to go off one of them and wonder which one would be better to wean off.
Taking bupropion and paroxetine?
Question posted by Cutri1895 on 16 Feb 2025
Last updated on 16 February 2025 by WildcatVet
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Answers
WildcatVet
16 Feb 2025
Hi, Cutri!
I wouldn't stop either one of your medications if they are working for you on the very slim chance of contracting serotonin syndrome. Combinations of antidepressant/anxiolytics from different classes are frequently prescribed together.
I've attached a link for you regarding serotonin syndrome and I think you'll see that it's very rare and easily treatable in the early stages. Plus if you were going to experience an interaction I would think it would have already happened after two years.
You're wise to be cautious and I hope the information in the link will help you and your doctor make the decision that is most to your benefit.
https://www.drugs.com/cg/serotonin-syndrome.html
Best regards,
Wildcat
Personally, I've taken bupropion for years with a variety of different antidepressants and have never had a problem.
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