Can I take tramadol, melatonin, and use calamine lotion at the same time?

Hello,

Drug Interaction Report
3 potential interactions and/or warnings found for the following 3 drugs:

calamine topical
melatonin
tramadol

All of the interactions as you can and will read are considered moderate, meaning:

Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Interactions between your drugs
Moderate
traMADol melatonin
Applies to: tramadol, melatonin

Using traMADol together with melatonin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Source and more info on potential drug-food interactions:
https://www.drugs.com/interactions-check.php?drug_list=454-0,1548-0,2221-0

Regards, masso