Last Thursday I was prescribed mirtazapine 7.5 for sleep and anxiety. I immediately quit taking trazodone which I have been on for 20 years at 50 mg. Is this OK? Should I have tapered off the trazodone or does the mirtazapine replace it? The pharmacist and my psych nurse didn't think it would be a problem. I am asking if anyone has ever done this? One antidepressant to another over night?