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Hypotension News

Related terms: Orthostatic Hypotension, Low Blood Pressure

Sudden Drops in Blood Pressure Tied to Higher Odds for Dementia

Posted 11 Oct 2016 by

TUESDAY, Oct. 11, 2016 – There seems to be an association between sudden drops in blood pressure upon standing up – a condition called orthostatic hypotension – and an increased risk for dementia, according to a new study. The study of 6,000 Dutch people could only point to an association between sudden low blood pressure and dementia, and couldn't prove cause-and-effect. However, a geriatrician in the United States said the link is worth investigating. "The study adds to the increasing body of knowledge that links cerebral blood flow to cognitive [thinking] disorders," said Dr. Irving Gomolin, chief of geriatric medicine at Winthrop-University Hospital in Mineola, N.Y. The new study was led by Arfan Ikram and Frank Wolters, of Erasmus Medical Center in the Netherlands. They analyzed 24 years of data from more than 6,000 people and found that those with orthostatic hypotension – low ... Read more

Related support groups: High Blood Pressure, Hypertension, Dementia, Alzheimer's Disease, Hypotension, Mild Cognitive Impairment, Hypertensive Heart Disease, Lewy Body Dementia, Dementia with Depressive Features

Flamel Technologies Receives FDA Approval of Akovaz (ephedrine sulfate) for Surgical Hypotension

Posted 3 May 2016 by

LYON, FRANCE--(Marketwired - May 2, 2016) - Flamel Technologies (NASDAQ: FLML) today announced that the U.S. Food and Drug Administration (FDA) has approved the Company's New Drug Application (NDA) for Akovaz™ (ephedrine sulfate), a drug administered parenterally as a pressor agent to address clinically important hypotension in surgical settings. Flamel obtained NDA approval for Akovaz as scheduled on April 29 and is the first to receive approval from the FDA for ephedrine sulfate. Flamel expects to launch Akovaz during the third quarter 2016 in a strength of 50 mg/mL. "We are very excited to receive FDA approval for Akovaz, the third product from our Éclat portfolio, and in line with the PDUFA date expectations. Revenue expectations associated with this product were included in our previously issued 2016 revenue guidance of $110 - $130 million. Our Éclat portfolio of products, which in ... Read more

Related support groups: Surgery, Anesthesia, Hypotension, Ephedrine, Akovaz

Health Tip: Coping With Low Blood Pressure

Posted 11 Mar 2016 by

-- If you have low blood pressure that drops low enough, you can feel dizzy or as if you're going to faint. The U.S. National Heart, Lung, and Blood Institute offers these suggestions to help people with low blood pressure: Get up slowly after sitting or lying down. Move your legs before you start to stand up. Eat smaller, lower-carbohydrate meals. Avoid standing for long stretches. If that's not possible, move frequently and consider compression stockings. Drink lots of liquids, preferably drinks that contain potassium and sodium. Stay calm and avoid situations that are frightening or unpleasant. Read more

Related support groups: Hypotension

Dizziness After Standing May Hint at Higher Risk of Early Death

Posted 23 Sep 2015 by

WEDNESDAY, Sept. 23, 2015 – Dizzy spells that occur after you've been standing for a few minutes might be an early warning sign of a serious neurological disease and an increased risk of premature death, a Harvard study has found. For some people, this dizziness is caused by a gradual drop in blood pressure. And this "suggests the nervous system is failing and isn't maintaining blood pressure while you're standing," said lead author Dr. Christopher Gibbons, an associate professor of neurology at Harvard Medical School in Boston. The condition is called orthostatic hypotension, and between 29 percent and 64 percent of people suffering from this blood pressure decline died during the 10-year study, depending on how quickly they became dizzy. By comparison, only 9 percent of healthy people in the study's "control" group died. But, this study's findings don't mean that everyone who becomes ... Read more

Related support groups: Hypotension, Dehydration

Health Tip: Understanding Low Blood Pressure

Posted 10 Feb 2015 by

-- Hypotension, or low blood pressure, can occur for a variety of reasons and may cause lightheadedness or dizziness. The National Heart Lung and Blood Institute explains these risk factors for low blood pressure: Taking a diuretic medication, which causes the body to pass more urine. Taking a high blood pressure medication. Having a heart condition. Having a central nervous system disorder, such as Parkinson's disease. Being unable to move around for long periods, or spending long periods in a heated environment. Being pregnant. Read more

Related support groups: Hypotension

Flamel Technologies Announces FDA Approval of Vazculep

Posted 3 Jul 2014 by

LYON, FRANCE--(Marketwired - Jun 30, 2014) - Flamel Technologies (NASDAQ: FLML) today announced that the U.S. Food and Drug Administration (FDA) has approved the company's New Drug Application (NDA) for Vazculep (phenylephrine hydrochloride). Vazculep Injection is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. Flamel expects to launch Vazculep in the next few months in 1 mL single use vials, and 5 mL and 10 mL pharmacy bulk package vials. The drug strength is the same in all vials at 10 mg/mL. Phenylephrine hydrochloride is used in operating rooms and is injected intravenously either as a bolus or in a dilute solution as a continuous infusion. "We are extremely pleased to receive NDA approval for Vazculep from the FDA," said Mike Anderson, Chief Executive Officer ... Read more

Related support groups: Hypotension, Phenylephrine

FDA Approves Northera to treat Neurogenic Orthostatic Hypotension

Posted 20 Feb 2014 by

February 18, 2014 – The U.S. Food and Drug Administration today approved Northera capsules (droxidopa) for the treatment of neurogenic orthostatic hypotension (NOH). NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associated with Parkinson's disease, multiple-system atrophy, and pure autonomic failure. Symptoms of NOH include dizziness, lightheadedness, blurred vision, fatigue and fainting when a person stands. “People with neurogenic orthostatic hypotension are often severely limited in their ability to perform routine daily activities that require walking or standing,” said Norman Stockbridge, M.D., Ph.D, director of the Division of Cardiovascular and Renal Drugs in the FDA’s Center for Drug Evaluation and Research. “There are limited treatment options for people with NOH and we are committed to helping make safe and effective treatments ... Read more

Related support groups: Hypotension, Orthostatic Hypotension

Study: Low Blood Pressure May Weaken Brains of Some Heart Patients

Posted 10 Jun 2013 by

MONDAY, June 10 – People suffering from cardiovascular disease who have lower-than-normal blood pressure may face a higher risk of brain atrophy – the death of brain cells or connections between brain cells, Dutch researchers report. Such brain atrophy can lead to Alzheimer's disease or dementia in these patients. In contrast, similar patients with high blood pressure can slow brain atrophy by lowering their blood pressure, the researchers added. Blood pressure is measured using two readings. The top number, called systolic pressure, gauges the pressure of blood moving through arteries. The bottom number, called diastolic pressure, measures the pressure in the arteries between heartbeats. Normal blood pressure for adults is less than 120/80, according to the U.S. National Heart, Lung, and Blood Institute. For the study, 70 to 90 was considered normal diastolic blood pressure, while ... Read more

Related support groups: Hypotension

Lightheadedness Upon Standing Could Signal Heart Risk

Posted 19 Mar 2012 by

MONDAY, March 19 – If your blood pressure drops suddenly when you stand up, leaving you feeling lightheaded or woozy, you may be at greater risk for developing heart failure, a new study suggests. This condition is known as orthostatic hypotension. According to the study, people with orthostatic hypotension were 54 percent more likely to develop heart failure than their counterparts who did not develop low blood pressure upon standing. This risk was reduced to 34 percent when the researchers teased out those who also had high blood pressure. "Multiple risk factors can increase a person's risk for developing heart failure, including high blood pressure, coronary heart disease and diabetes," explained study author Dr. Christine DeLong Jones, a preventive medicine resident at the University of North Carolina at Chapel Hill. "Orthostatic hypotension may also increase this risk." Heart ... Read more

Related support groups: Congestive Heart Failure, Heart Failure, Hypotension

Drug in Limbo, Catch-22 for FDA

Posted 26 Sep 2011 by

From Philadelphia Inquirer (PA) (September 25, 2011) Sept. 25--The normal tug-of-war between a pharmaceutical company and the U.S. Food and Drug Administration over approval for a drug has been turned on its side with midodrine, a medicine that helps about 100,000 patients a year avoid the potential dangers of low blood pressure. Shire Pharmaceuticals Inc., with U.S. headquarters in Wayne, no longer makes the drug, but it wants the FDA to give final approval of midodrine to lift a regulatory cloud. Barring that, it wants the FDA to approve Shire's plan for new trials or hold a hearing that might kill the drug. Though it has been on the market for 15 years under a temporary approval, midodrine never passed its final clinical trials. Now, the FDA is in a bind no matter how it acts, including doing nothing. "It is a Catch-22," said cardiologist John Harold of the Cedars-Sinai Heart ... Read more

Related support groups: Hypotension, Midodrine, ProAmatine, Orvaten

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Related Condition Support Groups

Hypotension Secondary to Hemodialysis, Cardiovascular Conditions and Disorders

Related Drug Support Groups

phenylephrine, norepinephrine, midodrine, ephedrine, ProAmatine, Northera, droxidopa, Orvaten, Levophed Bitartrate, Levophed, Vazculep, Akovaz, Corphedra