Simvastatin - has anyone experienced swelling in ankles and legs while taking this?

Yes I have had this problem as well, my foot and ankle has been so swollen that I have not been able to wear shoes. It’s only since I was put on simvastatin 40mg my Dr refuses to believe this is down to the tablets. I’ve stopped taking them it’s only been two days but there’s a marked improvement in the swelling.

Yes, I too have swollen feet and ankles. I have only been taking Atorvastatin for a month now. Emailing my doctor about it.

I have been on Simvastatin for years and the last couple of years I've had swelling in hands, face and leg, but after back surgery I've had severe swelling. My face, hands and especially my right leg and ankle feel almost unbearable. My doctor just switched me to Crestor to see if it helps. It is also a statin, but it's worth a try to see if it helps. I hope it does, I'm tired of the swelling never going down.

I did not experience it while taking it routinely however I did have a problem with it after surgery and was removed from the medication. I recently had lower spine surgery (L3 - S1). Approximately 4 days after I returned home from the hospital and about 9 days after surgery, my legs suddenly swelled incredibly - about 3 x their normal size. I was wearing compression stockings during that time. I could not wear my socks or shoes - had to use my husband's because my feet and ankles were so big. The swelling included my entire legs but was most prominent below the knee. After immediately ruling out DVT or other obstructions, my Neurosurgeon indicated that I should be removed from Simvastatin medication as it can be a cause of swelling. Within a couple of days of my ceasing the medication, my legs were right back to their normal size.

The symptoms you are describing are serious side effects of simvastatin. Please see your doctor immediately if you haven't done so already.

https://www.drugs.com/sfx/simvastatin-side-effects.html