I’ve had episodes of anxiety and depression since I was 30 , when my young son had cancer , thank God, he is fine , I’m 58 now and this is my 4 th episode over the years , a life changing event happened in November when my new grandchild was born with a syndrome, the vomiting started and I felt so low and useless , I immediately went on ciprilex upped to 20 mg after 3 months not a great improvement, on sertraline 100mg now 2 weeks , morning vomiting has stopped but I feel so uptight and my appetite is awful , was bad on ciprilex also , I go to work every day but it’s afternoon before I settle , I take propranolol ( beta blocker) once or twice a day . Any similar experiences out there ?