Sertraline - Is it normal to have a day with no side effects and the next day extreme side effects?

Today is my 2nd day on 50mg. I been tired in the morning. After lunch time I feel better. I also take .05 Klonopin to help with day time anxiety. Hopes this works for better.

For me Ive had the tingling feelings for 4 yrs now. With and without sertraline. It makes me pee small amounts at night often enough, that Im depressed about the side effects and want to taper off completely! It can cause an over active bladder in the evening hrs, so dont drink too many fluids, Xanax XR 3 mg
Supposed to work for 24 hours!
It only helps for maybe12 hrs. Its generic . I’ve suffered from anxiety and depression for 37 yrs
At 63 years old I am damn tired of feeling sick and tired every day

Hey, Pam!
We call it the "roller coaster effect"... the ups and downs of initial adjustment and many people experience it. It'll pass so hang in there. You're doing fine and not going backwards. It will only get better as you start to see more improvements!

Not every day can be great, you have been on this antidepressant for a week, your organism is still adjusting to the medication, most commonly this SSRI one starts seeing positive results within the the first 2 weeks and for the full therapeutic benefit it may take 4 to 6 weeks and there will be some days were you may feel as you have felt now, but that does not mean it is going to be like this for most of the time. You said you were feeling good with 25 mgs and I told you this was not a race to double the dose, give it another week with the dose you are on, if you start feeling bad then contact your Dr. and increase the dose to 50 mgs..