Is it safe to take metformin while on a low calorie diet of 450 calories per day?

I totally agree with every answer above! That is not enough calories for anyone. Much less a diabetic. You are going to feel fatigue and tired. That sounds dangerous to me. I would consult my Physician and increase my calories with veggies and fiber at least. Foods that are good for your body. hope this helped, I am definitely not a doctor. But that is not the proper way to lose weight. Well wishes and good luck.

You need more then 450 calories a day

dear murrypuss, i am NOT a doctor, but 450 calories a day??? That is NOT enough, even for a well person. Just 6 months ago I was paralyzed from neck down by potassium levels too low. Was told it could have affected organs next had I not rec'd treatment when I did. Your body will not react well with that few calories, hon, and can be very dangerous. Please talk to someone before you start this...

That level of diet is going to cause you trouble. See a dietician after you talk with your physician. You can't do it all at once and a crash diet like this will give you a huge rebound effect of even more weight. Slow and steady gets and keeps results. Please don't start this diet until your medication is adjusted. Low sugar readings are deadly, you know.

You should not start any diet without consulting with your doctor. You are on medication that is based on your caloric intake now. I hope you don't plan on doing anything if you're on that low of calories, its not enough to keep you moving and can lead to a dangerous condition called acidosis.