I just started using Picato gel last night. I thought I read all the directions, but after I had already applied it, I saw that it said not to apply it less than two hours before bedtime, but it doesn't say why. I didn't want to waste the application so I went to bed anyway about 30 minutes after applying it. Doing it before bedtime seemed like a good idea, but I guess I was wrong. Just wanting to know the reason why.