Why is it recommended not to apply Picato gel less than two hours before bedtime?

I used Picato 0.15% for my upper lip. I kept putting it off for fear of the unknown. I was afraid my upper lip would go black and blister, as my Dr warned.
It was the opposite. Yes it went red anf blistered for about 4 days but then it was just flaky skin.
Day 1 no pain, day 2 burning, day 3 burning as if someone held s lighter to my lip. Hurt. But day 4 the pain lessened. Day 8 lip still red (almost as if i was licking upper lip and chapped). No one noticed anything different. Day 10 all healed.
My recommendation is DONT put cream on at bedtime. The burning will keep you up all night. I put my cream on shortly after dinner each day. After day 3 I applied hydrocortisone cream (that dr prescribed me) for the next 7-8 days. I think the hydrocortisone sped up healing process. Also Advil, if needed.
Honestly this process was not that bad. I was expecting a lot worse. I planned this process to start on a Friday with Monday being a holiday (and took tues. We’d) off work as well.