... and popping when swallowing or yawning. I have read many of the side effects and reviews of prednisone, do the side effects come on when taking it for long period of time? Is this an OK dose? I was told by another doctor it is and it's the boost treatment. I have had issues with palpitations in the past and am afraid it may come up again after reading all these reviews. Advice would be greatly appreciated as I am afraid to even take this. I have taken 20 mg for 10 days in the past but with no side effects. But I'm thinking with this higher dose for a shorter duration of time that the side effects would occur.