Can I take Nyquil after only 1 dose of 50mg Zoloft?

Hello Vgutt
I. think you answered your own question as to take...
You side effects are darn rt scary. I.e aggression, irritation, thoughts of death?
Yikes!
What to try now?
Because you had what I call moderate-to-severe side effects I would consult your doctor before trying anything else.
Final idea, when you are awake and functioning despite your cold symptoms try to drink as many fluids as possible.
There's enough uncertainty here between the two drugs you definitely don't want to be dehydrated as well. I feel silly telling you this because I'm sure you knew to drink, drink & drink, esp with the cold.
Feel better!
bestpup

Hi, Vgutt! Since Zoloft has a long half life of approximately 26 hours, about 25mgs are still in your system. The use of any product containing dextromethorphan is contraindicated with SSRI class antidepressants so I would be very careful... serotonin syndrome is very rare but serious. Can you take your melatonin instead even though it won't help with your cold?
It would seem, also, that you are sensitive to these medications as the symptoms you described experiencing after taking your Zoloft, while common, mild, and to be expected, were exaggerated. You probably should have been started on the 25mg dose instead of 50mg.
Best regards and I hope you feel better soon!