No, tapentadol, or Nucynta, is kind of a "newer generation" drug in the same family as tramadol. They both have both analgesic action and norepinepherine reuptake action like antidepressants do. This makes Tramadol and Nucynta very different from other opioids. Nucynta is much stronger, I believe than tramadol but weaker than morphine. I think it is a schedule II drug where tramadol is either not a controlled substance or a schedule IV (some states may be a III) depending on where you live.
According to literature: Tapentadol is 18 times less potent than morphine in binding to the human mu-opioid receptor and is 2–3 times less potent in producing analgesia in animal models. Tapentadol has been shown to inhibit norepinephrine reuptake in the brains of rats resulting in increased norepinephrine concentrations. In preclinical models, the analgesic activity due to the mu-opioid receptor agonist activity of tapentadol can be antagonized by selective mu-opioid antagonists (e.g., naloxone), whereas the norepinephrine reuptake inhibition is sensitive to norepinephrine modulators. Tapentadol exerts its analgesic effects without a pharmacologically active metabolite
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Posted 17 Nov 2010 • 1 answer
Posted 19 Jan 2011 • 1 answer
Posted 18 Oct 2011 • 2 answers
Posted 1 Aug 2014 • 8 answers
Posted 20 Oct 2016 • 0 answers