Hey, Ellen! No interactions are shown for Wellbutrin, Motrin, Voltaren and so on. Some animal studies do suggest that NSAIDs may decrease the effectiveness of SSRIs (a different class of anti-depressants ~ Wellbutrin is classed as an atypical). If you're taking high doses or using NSAIDs frequently though, you should talk with your doctor or pharmacist.
I have advice, if not an actual answer, based on my experience. I have been taking high doses of NSAID (naproxen followed by Diclofenac) for the last 8 years for osteoarthritis. I also take Bupropion(Wellbutrin) ER150mg once per day for mild depression. A recent colonoscopy discovered a couple ulcers and a stricture in my proximal ascending colon. I am a 65 yr old male with a history of alcohol abuse (8 years sober). A known side effect of bupropion is constipation caused by a decrease in peristalsis. It makes sense to me that the slower the transit time the better the chance of NSAID induced lesions. I would still have developed colonic lesions eventually but maybe it happened earlier due to the Wellbutrin.
- Wellbutrin Information for Consumers
- Wellbutrin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Wellbutrin (detailed)
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