I recently started taking 10 mg of methotrexate weekly for RA. I take it on Saturday mornings so that if I am tired the next day is Sunday and I can rest. For the last 3 weeks I noticed that I am getting a headache Sunday night that lasts throughout Monday. Could this be a side effect of the medication? or simply a coincidence?
Methotrexate and Headache?
Question posted by trustingsoul on 29 Aug 2016
Last updated on 12 July 2018
Yes. It is the methotrexate. My husband takes it on Friday mornings and on Saturday midday he gets a headache that lasts thru Sunday. Tylenol or ibuprofen doesn’t help. His doctor said to watch the caffeine but sometimes I give him excedrin and a Benadryl if it’s really bad. But even that doesn’t help if it’s a bad headache.
I'm having the same problem. I have been taking MTX for almost 3 years and the headaches are getting worse. I take MTX on Friday night and by Saturday evening or Sunday morning I'm having bad headaches that make me sick to my stomach, like a migraine. Was just wondering if anyone else was having this reaction or if headache was from something else.
- Methotrexate uses and safety info
- Methotrexate information for Healthcare Professionals (includes dosage details)
- Side effects of Methotrexate (detailed)
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