How can i safely stop taking methotrexate? I've been on it for rheumatoid arthritis for about 16 years, I also take 5mg predisone daily and 2000mg relafen, along with blood pressure meds, i'm 62, female, and have severe nodules on my hands feet and elbows, also they found nodules in my lungs 6 years ago, they tell me they're no big deal, easy for them to say. I also have frequent urinary tract infections; i'm so tired of all the meds, other than for pain, the side effects seem worse, can anyone relate to any of this?