What is the maximum safe dosage of Prednisone for an adult?

I have been on very high dose as well. 80 at home and over that when in the hospital. One doesn't sleep, feels like their emotions are out of control, easily startled and lots of anxiety. Let the doctor know right away as this can be treated. The prednisone will do its job and once the inflammation reduces, it will be lowered. Doses should be administered throughout the day and not all at once. Your job is to keep her calm and encouraged that she will be better and this is not forever. When we know it will end we do better. Generally the doctor gives Xanax or another medication to calm the patient. Be her advocate and get her what is needed. She is in a tough situation for now. Family support helps a lot. Blessings to her.

I am sure the physicians and pharmacists know your wife needs this dose... I have taken low dose prednisone for allergies and over 25 mg a day made me feel almost psychotic