I suffer from bipolar and borderline personality disorder. Im currently on 200mg of quetiapine in the morning but by 2pm it's warn off completely. I take another 50mg in evening but it doesn't seem to do anything as I have quite a high drug tolerance.. how long is it supposed to last? Also can anyone suggest anything I could maybe take a long side it? I'm also on 40mg of duloxatine. Thank you.also I cannot sleep I have not slept more than two hours at a time for nearly 3 weeks