I took a 150mg pill of fluconazole Tuesday morning and I got prescribed some nystatin cream and it still itches down there. And the skin is inflamed and has bumps I guess from scratching. but the inflammation it has went down some during the first day when I took the pill. I’m suppose to take a second pill next Tuesday. This has been going on for about a week. The doctor said that it’s a possibility it could be herpes too because of how inflamed it was but I haven’t been sexually active in about two months.
How long does it take for fluconazole to work?
Question posted by Kahuguley94 on 11 Jan 2018
Last updated on 24 October 2019 by abrow145
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
6 Answers

Vaginal thrush is a common condition caused by a yeast infection (Candida albicans) in the vagina and surrounding area.
Fluconazole is an antifungal medicine used to treat vaginal candida. It is usually given as a single dose in uncomplicated cases. It may be given a week later to ensure complete eradication although this is not generally recommended unless your case is severe or recurrent.
Fluconazole works by stopping the growth of Candida. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.
Genital herpes is a common sexually transmitted disease caused by the virus called herpes simplex (HSV). Most people with the genital herpes virus don't have symptoms and are unaware they have it. Generalised symptoms include:
- itching or tingling, burning, or pain
- painful red spots/sores that change to clear fluid-filled blisters
- redness or a rash around the genital area
- swelling of the genital area
- pain while peeing
- flu-like symptoms
- vaginal discharge.
The main treatment for severe genital herpes is an antiviral drug. While this drug will help to reduce the number of outbreaks you may have, and speed up the healing process, it will not cure the virus.
For more information visit:
I know this is really late, but I am currently taking fluconazole for a yeast infection after taking 2 weeks of antibiotics. I get yeast infections a fairly good amount and I have recently started using tea tree oil diluted in water soaked in a tampon and stuck in my vagina a couple times a day, and have also used boric acid vaginal suppositories you can buy on amazon and they work wonders. Just wanted to post a couple more natural remedies on here Incase anyone saw it.
Hello ladies.
I’ve also been suffering with persistent problems, BV with a positive swab, treated with antibiotics and then thrush.. then BV again... then thrush several times.. then had an IUD inserted... IUD removed... doxycycline for unknown pelvic pain... more thrush.
It just goes on. And on.
I take a probiotic, wear cotton pants, shower twice a day with just water.. eat healthy (most of the time), limited alcohol.
Sex is almost impossible these days. I’m so fed up. Any suggestions would be fab.
Thanks,
I had persistent candida issues, & cut out 2 things from my diet, & never have trouble unless I consume those again. The first was Quorn, & the second was sugar. I don't have to eat much Quorn, neither.
Sugar (refined, white) feeds a candida infection. Worth looking it up if you've not heard of it.
I also get thrush whenever I use antibiotics. I have to have Fluconazole at the end of the course of antibiotics, although I try never to use them.
I know this question is several months old but I’m sort of in the same boat. Recently i was taking antibiotics for bv (Metronidazole) a weeks worth.After treatment i began itching and having slight burning and irritation like i had a yeast infection. I took a diflucan the first day off of my antibiotics and 3 days later.I STILL HAVE SYMPTOMS!!I went back to the Dr and my gyn told me the antibiotics didn’t fully flush my system which is why it didn’t work. She prescribed me 2 more diflucan and i took one yesterday and i feel worse literally as soon as i took it. (Immediate itching)I just don’t understand why this is happening I’ve been tested for everything under the sun and also blood work! I’m in the clear. I also feel more nauseous and tired today. When will it work ??? Should i even risk taking the next pill??
Betty, I feel I am in the exact same boat. Did you ever figure anything out? I am miserable and just dont understand what this is all about. I am starting to wonder if it's a thyroid problem that is causing my vagina to feel so crazy?!
Honestly i feel that diflucan does nothing for me anymore but make symptoms worse..I’m trying to go the natural route.Plain Greek Yogurt (with live cultures) help tremendously with the irritation and it can restore your ph.I try to eat yogurt a little bit everyday and I’ll also insert yogurt into my vagina.Recently I have begun taking probiotics but the ones I’m taking aren’t doing much help. I ordered the Rephresh b probiotics for women because I’ve heard nothing but good reviews on it. Once it comes I’ll let you know how it goes.I know how frustrating it is to find someone who understands what you’re going through without having to actually talk about it .Its embarrassing to not have control of your body..but i hope you find a solution! Don’t forget until then plain Greek yogurt works wonders
I think it takes 3 days but in the meantime try an ice pack between your legs.It won't cure the problem but it will give you some relief in the meantime. It worked for me, I hope it works for you.
Yeast in infection takes time, as for herpes hope he did a culture to know for sure, I would pay him another visit if you have know improvement in a day or two.
Related topics
vaginal yeast infection, fluconazole, nystatin, candida infections, skin, prescription, cream, pill
Further information
Similar questions
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.