Does lithium reduce thyroxine production permanently? I am reducing lithium from 900mg (taken 35-40?
Question posted by mmmousemaid on 25 Sep 2021
Last updated on 27 September 2021
... years as no longer tolerated as well), and I wonder if the Synthroid dose has to be adjusted. I would like to distinguish possible hypomania from hyperthyroidism, in the reduction phase.
Thank you for any information you have. I have not been able to get a reply from general physicians
Added 27 Sep 2021:
I wonder if I should take more clonazepam during these excitabilty states and wait to see if I can recover to a stable state. I often wonder if the diagnosis of bipolar disorder was correct in the first place, it was so long ago.
An excerpt from the Journal of Psychopharmacology a study first published 31 Oct, 2019: "In most patients lithium-associated hypothyroidism seems reversible once lithium has been discontinued. Therefore, in such cases, TRT discontinuation could be attempted much more often than is currently done. It seems prudent to allow some weeks for the thyroid gland to recover before stopping TRT. Based on the limited evidence of our study, we can expect hypothyroidism to recur early after TRT discontinuation, if at all. Thus, it is advisable to monitor thyroid function for 3 to 6 months. TRT reinsertion should then only be reconsidered if there are unambiguous signs of hypothyroidism, such as persistently high TSH and low fT4." Hope this may be help. Wildcat