I took my first dose (296 strength) at 9:15 a.m. today. It is 6:10 p.m. I've had no progress; not a cramp or urges. I still feel miserably constipated and hopeless! My doctor told me to take the dose two hours before eating; I wanted exactly two and was starving. (I over slept today and changed plans to be near the bathroom). I drank usual amount of water, and two 6 oz. glasses of prune juice as well. I'd really appreciate some advice. Thank you!