I've been taking 20 mg dose Fluoxetine for 12 yrs and it has worked great. My Rx provider now uses a different manufacturer and I notice some increasing depression. Anyone else have this sudden change when switching between brands?
Fluoxetine - has anyone noticed worsening depression after switching brands?
I'm referring to differences between Generic Manufacturers of the same drug, Fluoxetine. My Doctor confirms this does happen. Any other experiences out there similar to this?
Hello rjlima98. By manufacturer do you mean generic versus non generic? there are often differences in certain drugs that we take. Some of us are very sensitive when it comes to generic versus non generic. Some drugs do have a noticeable difference. If you mean in your question say going from fluoxetine to a completely different drug altogether, then certainly, you might see a major difference. Not certain if I answered your question though.best to you.
whether you are referring to any differences between brand vs generic or generic vs generic, any manufacturing process can introduce chemical components that can impact how a person might react... differing side effects. now this is not related to the active ingredient, in this case fluoxetine, but rather to the other chemical agents used in the actual production of the pill... dyes, fillers, binding agents, etc. since you have a fairly lengthy history of use of the drug, it comes as no real surprise that you are reacting differently given that your medication is being supplied by a different manufacturer. because one specific pharmacy, or even a chain, generally will have established a contract with a manufacturer or wholesale provider (a business contract) you may not be able to do anything to address this issue, short of canvassing other pharmacies in your area to see if they can provide a specific manufacturer's product to you.
check with your pharmacist and see if they can special order your medicine. alternatively, you could contact the manufacturer directly and ask them if they can direct you to a pharmacy in your area that could provide you with the medication.
I recently switched to another manufacturer of 40mg fluoxetine (from Teva to Par), and the first two weeks on the new stuff was maddening to say the least. Within that period, I had about three days of intense anxiety--butterflies and the feeling of an oxygen rush in my frontal lobes--and one day with a severe migraine. It seems that the Par product is superior in its relative effectiveness, so the switch was like a sudden mg increase. This came as a result of switching between local pharmacies.
As was mentioned, each manufacturer synthesizes and purifies their drug differently. Crystalline structure and fillers can have significant effects on the mind. A simple analogy is rock candy: every rock is made from sugar, but each flavor changes the taste and/or color. So a filler can alter the effects of drugs just as flavors affect taste.
Additional chemical processes may alter the drug entirely: stereochemistry (mirror image), for example. A stereoisomer of a drug may be inactive altogether, and if the racemic mixture (mixture of mirroring compounds) is greater of one or the other(s), then that may have serious consequences on the effects.
Yes!! I feel like I quit taking it. It feels like I am taking nothing! I don’t know what to do. At this point I cannot remember which one worked.
All my meds are TEVA generics... they've always worked the best for me.
I learned early on to stick with the companies generic who makes the brand if possible. I have withdrawal when I get switched to a different generic in most meds. It reaks havoc. Just my opinion.
I got a refill of Fluoxetine from a different source than my usual Express Scripts. I was thrilled that it was so much cheaper but alarmed when I opened the package and saw a different pill. I am trying the Sandoz 20 mg capsule tonight to compare it to my former Aurobindo 20 mg Hcl Capsules. I hope to report back if a change is observed. Does anyone know why one says Hcl and the other does not say Hcl?
Yes, unfortunately it took me months to realize that the switch between generic brands was the issue. I had scripts filled at Sam's and they switched to a different brand. When Costco opened, they use a different generic Aurobindo, and it is amazing the difference... I won't go back...
Now that Sandoz doesn’t manufacture fluoxetine any longer has anyone switched to another generic that works? I tried Aurbindo and it didn’t work at all. Trying Mylan tablets and feel like they may be stronger as I am having headaches. Thanks for any insights.
To answer your question, yes, you will feel different for a few days after switching generics. You may think the new generic isn't working but you have to give it at least three weeks. At least that's the way it's been for me and I've been on and off these drugs for more than 25 years.
I am on 10mg fluoxetine a day. I'd been taking the Sandoz for about seven months and didn't really feel any different. I didn't want to increase the dosage because of sexual disfunction. Now that Sandoz stopped making fluoxetine I switched over to Aurobindo which was my last choice because I'd read so many bad reviews on it. Turns out it has been the most effective fluoxetine generic that I've been on so far. Essentially no panic or nervousness, just a feeling of being normal, and that's just with 10 mg. I have a compressed nerve in my neck that causes shoulder pain and after two days on the Aurobindo the pain was gone.
I'd had that pain for about 16 months.
Aurobindo has been a good generic so far and it's only been seven days.
I was diagnosed with major depressive disorder 20 years ago, simply put chemical imbalance, no life episodes contributing. I have been on generic fluoxetine via local pharmacy for years with little to no problems. However, upon switching to Express Scripts a couple of years ago I have been receiving a few different manufactures, most recently Aurobindo. Upon taking their med I experienced minor depression almost with a couple of days. This accelerated quickly into a full blown relapse which at times has been unbearable. There were hours of some relief followed by days of despair. I did some homework and found some concerns over this Indian based company. Also my local ParD just told me that there is rumblings that these companies based in India and China may not be following FDA guidelines. Obviously, it may work ok for most but not me! I have switched to Par Pharmacy tablets and just today am feeling much better, thank the Lord.
Any others with similar experience?
I switched to name brand via Canadian pharmacy. Huge difference. 49.00 plus 10.00 shipping. Two moths... so far so good:)
Par pharmacy worked well for me, however, I did my research and was able to use Canadian pharmacy to switch back to name brand Prozac manufactured by Lily in the UK. This has help stabilize me.
Pharmacies buy and dispense the least expensive generics that are available at any given time to save you money. If you are using or have used a generic that you feel works well for you ask the pharmacist to special order it for you... most chain and family pharmacies are happy to provide this service. You may pay a few cents more but it's worth it to have a medication that works well.
- Fluoxetine Information for Consumers
- Fluoxetine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fluoxetine (detailed)
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