can be interchangable? & 5 mg SL equal to 5mg tablet sr
Isosorbide Mononitrate - what is the difference between isosorbide monnitrate & isosorbide dintrate?
Question posted by shalenzi on 7 Aug 2010
Last updated on 16 August 2010 by Chaman Bajwa
Answers
Isosorbide mononitrate has one nirate group and isosorbide dinatrate has 2 nitro groups.
Sublingual isosorbide dinitrate and nitroglycerin are the two compounds used to treat acute angina.
Their those has to be increased sufficiently to be given in oral form in maintenance therapy as these are rapidly degraded by liver with very low bioavailability.
Isosorbide dinitrate is not degraded by liver and has bioavailability of 100% and so is used best in maintenance therapy.
Amyl nitrate inhaler is also available for acute angina.
Ismo (Isosorbide Mononitrate) tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
Isordil (isosorbide dinitrate) Titradose tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of immediate-release oral isosorbide dinitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.
For other details a doc could be the best person to answer your question, hope the little info does help ypu? Regret could not answer the full question.
thanks ,but both isosorbide chowable & sl have same onset of action
Pleasure, are you giving this info or asking me?
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heart failure, isosorbide mononitrate, isosorbide
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