Is it safe to take Antenex(Diazepam) While Im on Pristiq (My new anti depressent)?

A moderate drug interaction does exist between Pristiq and diazepam.
The combination could lead to an increase in CNS (central nervous system) side effects including
Feeling sleepy and uncoordinated,
staggering,
blurred vision,
impaired thinking,
slurred speech,
impaired perception of time and space,
slowed reflexes and breathing, and
reduced sensitivity to pain.
https://www.drugs.com/interactions-check.php?drug_list=862-0,2796-12488

While it is safe to take the 2 together you should be aware that you are more likely to experience the above side effects while on your combination of medicines.
Talk with your doctor if any of the above are an issue for you. You may of course not experience any side effects.
Be especially careful driving or operating machinery.
Hope this helps.