I had an infusion of Zometa yesterday and am experiencing great pain in my hands, knees, neck and?

I just experienced the same thing- severe muscle and joint pain to the point of tears. It was my 3rd dose and I did not have severe pain the previous times.
I called the Oncologist office today and they put me on steroids and 800mg Ibuprofen 4 times per day. The meds are helping as I’m not in severe pain now.
Please contact your doctors office if you’re in severe pain. No need to suffer.

I have been getting infusions of Zometa since 2005. The first few infusions, I too had great bone and muscle pain. My oncologist started giving me 50mg of benadryl prior to the infusions. It helps to alleviate some of the side effects, plus I am able to rest after the infusion since the benadryl makes me drowsy. I have also found that soaking in a hot bath helps with the pain and seems to relax the muscle spasms. Talk to your doctor. Benadryl works for me, but he might try something different for you. I wish you the best and pray that you feel better soon.