I have been on Ambien for close to 8 years now, once in awhile the pharmacist will give me the Generic brand (Zolphidem Tartrate). I've used it before and didn't have any problems but this last supply... I may get one night a week that I really slept. Again tonight, 3rd night this week, I've taken it and an hour later I am still wide awake. I am taking the 10mg tablet and was thinking of taking another so I can get to sleep.
Has anyone experienced sleepless nights while taking the Generic brand of Ambein?
Question posted by dadgs51 on 25 March 2011
Last updated on 20 June 2022 by Iglow
I’m a psychiatrist and prescribe Ambien/Ambien CR and the generic zolpidem/XR, cautiously, obviously, as I prescribe any medication .
I have seen people go from sleeping well and upon refill, its a new generic and its BLUE. Upon return to any generic zolpidem that is NOT blue, they sleep again.
I’ve also seen, prior to generic availability, people do well on Blue Brand Name Ambien CR for months of intermittent or nightly use, and then relatively abruptly have not just “it doesn’t work” insomnia but agitation, above and beyond what one would expect from a “rebound insomnia” that can occur if one taking it nightly for a period abruptly stops it.
That “feels” like sensitization to an allergen. Abrupt strong negative reaction after a period of multiple exposures, and the immune system works up a progressively bigger head of steam.
I have not read anywhere of studies showing IgE antibodies- a “true” allergy, but the immune system has more ways to respond to a “foreign molecule” than the IgE pathway. So, its an adverse reaction, of unknown body mechanism. In the goljs I’ve treated. I can’t obviously declare anything about someone I’ve not interviewed clinically. So, not diagnosing.
Sharing my observations and hope it is helpful.
I have seen this adverse reaction to blue non-sleeping pills as well. EG Bupropion XR 150 mg is fine until pharmacy gets a blue generic. Anxiety, physical agitation and nearly intolerable restlessness.
Dyes and excipients (plus if the generic is REALLY bioequivalent or just FDA 85-115% of the mg the label claims. REALLY bioequivalent is exactly the mg as labeled (brand name must adhere to this) and mechanism of release- extended, delayed or immediate must release the active ingredient at the same rate as brand name. That’s TRUE bioequivalence. Different than regulatory bioequivalence)
So, dyes, fillers and real bioequivalence (all of which vary from generic to generic) can cause actual problems.
Unfortunately, I think lots of patients are dismissed, and that sucks.
Doctors almost always fail to tell their clients that most sleep Meds should be taken on an "empty stomach."
I use to get one or two nights of sleep a week until I discovered the below routine.
When I take Ambien or Zolpidem Tartrate it only works for me if I take it after not eating for two hours. If I eat Posta I need to go three hours, at least, of not eating before I take the med. Sticking to this has been giving me good results!
Before I discovered the above routine I would take double the dose with good results but I was "out of it" for most of the next day.
Yes. The generic ambien IS NOT working for me.
Yes I have been having a lot of problems with generic Ambien zolpedian tartrate since my insurance company no longer allows name brand and it does make a difference when my son takes generic keppra XR for epilepsy he gets seizures if this generic meds are not exactly the same as name brand they should be illegal my son and others could die from this
I find if the first doesn’t help I take another. Still wide awake but afraid to take any more !
I take the same thing and it isnt working now.and yes i have to take 2 most of the time and yet they will not double the dosage so i now have not enough to last.and it takes 2 for me to go to sleep and stay asleep because i have been on them for so long.they should up the dose or find something that doesnt affect us in the long run.so i know exactly what you mean.IT SUCKS
I have taken Ambien for 7 years (2-12.5mg pills dr prescribed it) I too switched (well insurance switched me) to the generic cr. It was AWFUL!! I use generics and I loved the fact that I could save some money. I could not sleep and the few hours I did sleep I had awful nightmares. Ask the Dr. to tell the pharmacy you NEED the real thing. That is what my dr did
I started taking Ambien 10mg about 8 years ago. I took that until they came out with the CR. Then I started taking 12.5 mg of the Ambien CR everynight. I have stayed on this and had no problems with tolerance or anything like that. HOWEVER, a few months ago my pharmacist asked me if I wanted to try the generic. They finally have a generic for the CR, until a few months ago it was only available without the control release. I got the generic, and it was just as effective.
Last month I filled my script at a different pharmacy, and they use a different manufacturer for their generic. I know that it's supposed to work exactly the same. I use generics for ALL my medications, and have never had a problem. But this particular brand of generic didn't work at ALL. The first couple night I had convinced myself that I was just imagining it. But the entire month I just couldn't sleep.
This month I went back to my regular pharmacy, and still the generic, and it's back to working wonders. Maybe try a different pharmacy who uses a different manufacturer for their generic.
Yes, largely sleepless since getting generic Zolpidem tartrate ER 12.5, the generic for Ambien CR. It makes me feel nauseated, and dizzy but I can't fall asleep until about 4 hrs after I've taken it. Then I sleep about 4 hrs. It's getting pretty bad. The blue branded Ambien CR 12.5 worked well for a few years now. On a bad night, I'd get 5 or 6 hrs but sometimes slept 7 or 8 and that was wonderful. I don't like this generic AT ALL!
I've been on Ambien for several years myself, and stopped taking it due to decreased effectiveness (you may have built a tolerance to the medication, after taking it for so long). My old doctor frowned upon prescribing 20mg per night instead of 10, and so did the pharmacy and insurance company when my newer doctor was actually willing to do so. They questioned if I was "pharmacy shopping" and other things, and in order to get it through insurance, I had to have a prior authorization (PA, the pharm calls it), and they would only approve 1 per night. So, generally, I doubt that a double dose will do much for you except make your supply run out more quickly.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.