I have been taking fluoxetine for 4 years now. For the first 3 years they were from the same manufacturer. A couple of months ago the pharmacy I collected my prescription from changed manufacturer, but I didn't think anything of it because I assume that they have to be manufactured 100% the same. Anyway, I have been feeling extremely low in mood, aggitated, anxiety, whole body aches, headaches and generally run down for the past couple of months. I have been to my doctor where I had blood tests to rule out a number of issues. Everything came back normal. I am still feeling awful, and I was wondering if this could have anything to do with the current fluoxetine I am on. Is it possible that there is a difference between the new and previous fluoxetine? I am very sensitive to medication so even the smallest change is likely to affect me!!!