I have been taking fluoxetine for 4 years now. For the first 3 years they were from the same manufacturer. A couple of months ago the pharmacy I collected my prescription from changed manufacturer, but I didn't think anything of it because I assume that they have to be manufactured 100% the same. Anyway, I have been feeling extremely low in mood, aggitated, anxiety, whole body aches, headaches and generally run down for the past couple of months. I have been to my doctor where I had blood tests to rule out a number of issues. Everything came back normal. I am still feeling awful, and I was wondering if this could have anything to do with the current fluoxetine I am on. Is it possible that there is a difference between the new and previous fluoxetine? I am very sensitive to medication so even the smallest change is likely to affect me!!!
It is possible due to the inert ingredients being different which can cause allergic-type reactions for some people. Otherwise the active ingredient, fluoxetine, must be the same though not necessarily in the same percentages. Manufacturers are allowed a range as far as the concentration. They must be something like between 80% and 120% of the target dosage. There is a book called the Orange Book that lists different manufacturers and meds and their respective ranges, but hard to get hands on except by a pharmacy.
Haggis_08; Laurie has the inactive ingredients correct as far as different manufacturers use different inert or binders with generics but the active ingredients now THE ORANGE BOOK IS WAY OUTDATED and very few pharmacies even can get it anymore this was back with generics were only listed by AB ratings and they had a larger range in active ingredients allowed by the FDA NOW DAYS no matter if it is a brand name drug or an Generic drug the difference in active medication allowed is only 3.5% maximum the FDA has really tighten the regulations on the generic and brand after the Synthroid class action law suite. so if there is a reaction to a generic you can bet it is from the person taking it is having a problem with the Inert ingredients.THIS CAN ALL BE VERIFIED AT THE FDA WEB SITE AND HOW THEY CHECK THE BRANDS AND GENERICS FROM BATCH TO BATCH with blood draws at the same point as brand to check % of drug at different hours.
chuck1957 Charles E.Wise Sr. Medically retired Pharmacy Technician Cpht. info also from current test taken 6-15 Phar.Tech Topic. for new certification Chuck.
haggis I forgot What you can do is take it back to the pharmacy and request the company you have always been getting and if they can't get it anymore than you need the name of the company and call around and see if you can find that generic brand it can be something as simple as a salt,or lactose that does not agree with you
Chuck's correction of above Laurieshay is correct on still the Orange book you can look it up now on the FDA site here is a paste.from it. I am so sorry for messing up this question. The AB rating is for the 3.5% active Ingredients in the generic drug or Brand drug. All drugs in the USA generic listing must fall into the AB rating But none are rated from 3rd world countries Which is why they don't recommend us to order medications that way.Many tested have been completely different than what is claimed.((((Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations
Print Share E-mail
FDA HomeDrug DatabasesOrange Book
Current through October 2015
To provide timely consumer information on generic drugs, the Electronic Orange Book is updated daily as new generic approvals occur.)))) Laurie I am so sorry that I got confused about this. but the generic part is correct Chuck1957
I tried to message you but my friend list does not work and it goe''s out as a question So I hope you see this before it is removed Chuck
- Fluoxetine Information for Consumers
- Fluoxetine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Fluoxetine (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.