Can fluorouracil 5% Topical Cream be used for toe nail fungus?

you can use vicks rub on your toenails. you may try tee tree oil. the prescripton is very expensive $250.00 or more. your insurance probably will not cover it- its an external application . there is a pill, also expensive . It can be lasered. talk to a dermatologist or a podiatrist. they are experts and will explain the alternatives the best time for alternative treatments is after nails are cut. It is a fungus... fluorouracil is only for cancers. I have used it for years. It will not work on fungus.

No, fluorouracil cream won't really help with toe nail fungus. You need to apply some sort of antifungal product. If the infection is really bad then it might be a good idea to see your doctor and get something to take orally.

https://www.drugs.com/condition/onychomycosis-toenail.html

Fluorouracil interferes with the growth of skin cells. Fluorouracil works by causing the death of cells which are growing fastest, such as abnormal skin cells.

Fluorouracil topical is used to treat scaly overgrowths of skin (actinic or solar keratoses). Fluorouracil topical may also be used in the treatment of superficial basal cell carcinoma.

https://www.drugs.com/mtm/fluorouracil-topical.html