I use 1 gram of Estrace Cream three days a week. I receive a 42.5 g tube every three months. While the math is right, one tube seems to last only slightly more that 2 months. I use the applicator that comes with it, filling only to the 1 gram mark each time. Insurance does not allow me to reorder until the end of the 3 month period, which means I go without for 3 weeks. (I use this medication for an autoimmune disease and experience painful flares when I miss a dose.) Has anyone else had the same problem of running out of medication too soon? What am I doing wrong?