Efudex - How do I recognize the side effects of applying Efudex?

Yes, Efudex cream (fluorouracil) can potentially cause systemic side effects even when applied to a small area, although this is less common with limited application.

Most side effects are localized to the treatment area (redness, burning, pain, irritation, inflammation, swelling), but some people experience systemic effects including: Flu-like symptoms (fever, chills, fatigue), Nausea, Headaches, Dizziness, Insomnia, Irritability or mood changes.