Constipation is also my problem. My doctor lowered the dose from 50mg to 20mg... in hopes that I would not be constipated. I will try to take 20mg every other day and see if it makes a difference. Hopefully, it won't cause me withdrawal symptoms! My heart rate is also increased w/this drug, I don't need that problem since I'm on Xanax .5mg 3times a day for my anxiety. Does anyone have similar problems with duloxetine?