What is the difference between oxycodone 10/650 and oxycodone 10/325?

that should be that you SHOULDN'T feel a big difference in how they work. You probably wont feel much difference at all.

As of January 1, 2014 all medicines containing Acetaminophen (Tylenol) will have only 325 mg (such as hydrocodone/APAP [APAP means acetaminophen which is the generic name forTylenol], oxycodone/APAP, etc) per pill. This is due to the toxicity of the acetaminophen to the liver. The acetaminophen adds very little added pain relief, if one has to take a pill with oxycodone/APAP or hydrocodone/APAP. But the higher amount of acetaminophen (that is 500 mg acetaminophen (APAP) or 650 acetaminophen (APAP) per pill that were in these pills before January 1, 2014 were more toxic to the liver, if one takes more than 4000 mg acetaminophen when a person adds up the total number of these pills taken per day. Therefore by lowering the amount of APAP down to 325 in hydrocodone or oxycodone, there a lower amount of APAP so thus there is less toxicity to the liver if one has to take several hydrocodone or oxycodone pills containing APAP per day.