Just the name.
Macrobid is a longer acting time release formula taken twice a day and macrodantin is the regular immediate release and needs to be taken more often-usually 4 times a day. They are both nitrofurantoin.
Macrobid is in macrocrystal form as opposed to microcrystals. The larger crystal form takes longer to be absorbed and excreted thus the twice daily as opposed to 4 times daily dosing!
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