Does anyone know if Trulance causes depression and panic attacks.? I have been taking the 3mg. every morning after breakfast for months now and I have developed terrible depression and panic attacks which awaken me from my sleep. I take the 3mg for chronic constipation and IBS. It does not seem to help but neither did Linzess. Depression is not listed as a known side effect, just diarrhea, which I have not had. Thank you for any help or info.