I had trouble with restless leg syndrome after I was on fluoxetine for several years. It got so bad, I decided to stop the fluoxetine (and boy, was that hard!!! ) After trying citalopram (good for depression but not anxiety) and bupropion (ineffective for depression and anxiety) without success, my pcp has decided to try me on Cymbalta. No matter when I take it, it is causing RLS. Has anyone else had trouble with it like this?