I was on opiods for pain, but the withdrawal did not even come close to what I am going through with Cymbalta. The brain zaps and rapid moods swings have diminished to almost zero, but I am left with a profound depression, unlike anything I have experienced. I am determined to succeed. I am also irritable, unbelievably so. I need encouragement. Can only take MAO Inhibitors now. Don't want to go there.