... any less effective. Is it possible it is effective enough?
Time release medication: extended-release (ER, XR, XL).-
Do not crush, chew, or break an extended-release bupropion tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time, which could increase side effects including seizures.
All the best,
For those on the XL forms of Wellbutrin or bupropion hcl, wouldn't it make sense to titrate the med by changing the total dosage by increasing or decreasing the dosage by a complete tab to every other day. Given the steady state levels achieved and the XL's half life and method of metabolism, if increasing from 150 mg to 300mg total daily dosage, take 1 - 150mg tab daily and an additional one only every OTHER day for 1 week ( or longer if very sensitive to side effects)and, if tolerated, move to 2 tabs daily (300mg total)?. Conversely, if downward titration is desired from 2-150mg tabs daily to 1 daily AND 1 every other day for length of stabilization, then 1-150mg tab daily, and finally, a reduction to 1-150mg tab every other day until desired effect for maintenance?
I just spoke with my Pharm D. about this. The active ingredient in Bupropion xl is mixed with the binding agent throughout the entire tablet. It is not just the casing. Therefore, it is fine to split this specific extended release tab to achieve a lower dose.
I was having issues with my recent refill (generic) and the timing of the release being off. My thought is that it was a bad lot. I was taking the whole 300 XL at 7am, then by 12:00 noon it felt like I got hit by the Bupropion truck... lol. It was releasing all at once, leaving me with some crazy anxiety and panic attacks out of the blue. I am not prone to these, and through process of elimination, can only attribute it to these specific meds and their release timing. I have decided to get off the Welbutrin train and switch to Lexipro. Since I have a ton of 300mg XL tablets, I wanted to just split them to start tapering.
Looks like im good to go.
Hope this answers any questions and provides some clarity about cutting these tablets.
- Bupropion Information for Consumers
- Bupropion Information for Healthcare Professionals (includes dosage details)
- Side Effects of Bupropion (detailed)
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