The major side effects of NSAIDs are related to their effects on the stomach and bowels (gastrointestinal system). Some 10%-50% of patients are unable to tolerate NSAID treatment because of side effects, including abdominal pain, diarrhea, and upset stomach. Approximately 15% of patients on long-term NSAID treatment develop a peptic ulcer (ulceration of the stomach or duodenum). Even though many of these patients with ulcers do not have symptoms and are unaware of their ulcers, they are at risk of developing serious ulcer complications such as bleeding or perforation of the stomach.
Common side effects of NSAIDs may include the following:
Extreme weakness or fatigue
Serious side effects of NSAIDs may include the following:
Allergic reaction, such as difficulty breathing, hives, swelling of the lips, tongue or face
Muscle cramps, numbness or tingling
Rapid weight gain
Black, bloody or tarry stools
Bloody urine or bloody vomit
Decreased hearing or ringing in the ears (also called tinnitus)
Jaundice (the yellowing of the skin and the whites of the eyes)
Call your doctor as soon as possible if your side effects become severe.
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