I have done this. I use .05% strength. The only thing I would be careful about is what KIND of cream you were mixing with it. It will dilute the strength of your cream, but I know that my skin gets very flaky in winter if I do not do this occasionally. I would only use a cream "base" to mix with it... some examples of cream bases would be Moisturel or Glaxal Base... these creams are called "bases" because they are very simple creams/lotions that do not contain additional additives that may interact with the tretinoin in your cream.
Sometimes about an hour before bedtime, after washing my face, I put on Glaxal Lotion or Moisturel Lotion and in an hour it will have usually "sunk" into my skin... then I apply the Retin A... lotions are more readily absorbed into your skin... and that way you are still getting the full strength of your Retin-A. In winter, I usually try to alternate 2 strengths... I will use 0.25% one night, then 0.5% the next.
I hope this helps:)
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