I've been taking Bupropion for depression (as well as lithium) as it seems like the only drug that does not cause me to gain weight. After some research and answeres some of you have provided me with, bupropion and lithium may not be the best combination of drugs. Also, being bipolor I wonder if this is the right drug for me. Maybe this is whats causing me some of my anxiety. Can anyone recommend something else to take that will not cause weight gain or worsen by manic episodes?