Are there any issues ussing these 2 together (Zoloft & Metoprolol). Thanks?

Hi, beatlefan! Because of the half lives of these drugs separating your doses wouldn't be all that helpful. Metoprolol stays in your system for about 24hrs and Zoloft even longer.
It's a benefit ~vs~ risk situation that your doctor should be aware of when prescribing these two medications, but if you should feel extreme dizziness, lightheadedness, fatigue, shortness of breath, chest pains, or tiring during physical activity let your doctor know as another beta-blocker may be more appropriate for you. This is most apt to occur when first starting these medications... if you've been taking them for awhile an interaction is more unlikely.

This is an old post but I had a question. I just got prescribed metoprolol succinate xl (25mg) and I take 100 mg of Zoloft. I see there is a moderate interaction between the two so when should I take them? One in the morning and one in the evening? It just worries me since there says there is a moderate reaction between them. Thanks

I have used both of those and didn't feel great taking either one. It really depends on the medication and how it works with your body. I took Metroprolol because my heart rate would go up to 300 beats per minute. It did help my heart but it made me very lethargic and that was because it was lowering my blood pressure when I already have hypotension. If your blood pressure isnt low you should feel fine. Zoloft never worked for me, but it did work for others. I was taking celexa with metroprolol which is just like zoloft and I was ok. suggest if you feel weird at all to talk to your doctor.