... months ago along with 20mg x 2 p/day of omeprazole and after a few weeks my ankles were extremely swollen, i thought it the anti-inflammatorys to blame and stopped both and after a couple of days ankles were normal. Last week i was prescribed a low dose steroid and again omeprazole and after a week or so my ankles have swollen again, i stopped the omeprazole yesterday and again my ankles have improved