Hi, I started taking just 5 mg. of methotrexate each week for my Seronegative RA. I only did 2 weeks worth and the doctor asked me to hold off until I get the headaches checked out. I do not have a headache hx. and they started almost immediately after starting. I still have these headaches almost 2 weeks after my last dose. They move from the back of my skull to the forehead area. I have not been getting regular sleep since being on Prednisone (10 mg/day) plus it is the change of season (upstate NY). Seeing my primary tomorrow. Any help would be appreciated.