How soon after starting Zetia will side effects start such as aches in joints and muscles last?

I was on Zetia but also Lipitor at the same time. If you have any aches in your joints and muscles, I would advise asking your doctor to take you off of any statin drugs. My aches did not start and the blood tests never showed any problems until it was too late. Now the muscles in my legs are destroyed. I cannot walk for more than 20 minutes without extreme pain.Your doctor may or may not believe that it is from this drug as several of my doctors still do not believe my pain is from those drugs. It will be up to you then to decide what to do. If you stop the drug, and your aches go away then this should be a sign the drug is the cause. We are all different so this is a decision for you to make if you feel better without the drugs. Look up side affects of Zetia and show them to your doctor and if it shows muscle aches, then he will probably take you off of them.