Versed Side Effects

Generic Name: midazolam

Note: This page contains side effects data for the generic drug midazolam. It is possible that some of the dosage forms included below may not apply to the brand name Versed.

It is possible that some side effects of Versed may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to midazolam: oral solution, oral syrup, oral tablet

Other dosage forms:

As well as its needed effects, midazolam (the active ingredient contained in Versed) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking midazolam, check with your doctor or nurse immediately:

Less common
  • Anxiety
  • chest pain or discomfort
  • choking
  • confusion
  • difficult or troubled breathing
  • drowsiness
  • dry mouth
  • fast heartbeat
  • hyperventilation
  • irregular heartbeats
  • irregular, fast or slow, or shallow breathing
  • irritability
  • lightheadedness, dizziness, or fainting
  • nausea
  • nervousness
  • noisy breathing
  • pale or blue lips, fingernails, or skin
  • restlessness
  • shaking
  • shortness of breath
  • slow or irregular heartbeat
  • tightness in the chest
  • trouble sleeping
  • unable to speak
  • unusual tiredness
  • weakness
  • wheezing
Rare
  • Attack, assault, or force
  • changes in patterns and rhythms of speech
  • feeling of constant movement of self or surroundings
  • headache
  • lack or loss of self-control
  • loss of balance
  • mood swings
  • noisy breathing
  • not breathing
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • sensation of spinning
  • shakiness and unsteady walk
  • sleepiness
  • slow to respond
  • slurred speech
  • trouble in speaking
  • unconsciousness
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking midazolam, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • difficulty with coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Some midazolam side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Vomiting
Less common
  • Rash
Rare
  • Blurred vision
  • double vision
  • gagging
  • hiccups
  • seeing double
  • watering of mouth and drooling

For Healthcare Professionals

Applies to midazolam: compounding powder, injectable solution, intravenous solution, oral syrup

Respiratory

Respiratory side effects, which have included cardiorespiratory depression, apnea, and respiratory arrest, are extensions of the drugs pharmacologic activity.

Personnel and equipment necessary for the treatment of respiratory depression and arrest should be immediately available whenever midazolam is administered.

One retrospective study has reported that the frequency of respiratory arrest (in nonventilated patients) is 0.099%. This study reported that respiratory arrest was associated with high doses of midazolam, concurrent administration of opioids, and advanced age.

Another study has reported that midazolam causes a decrease in tidal volume, an increase in breathing frequency and no change in minute ventilation in healthy volunteers. That study, however, did report a significant increase in CO2 retention following midazolam administration.

Cardiovascular

Cardiovascular side effects including alterations in blood pressure, arrhythmias, and ventricular irritability have been reported. Hypotension and decreases in systemic vascular resistance have been reported most frequently; however many investigators have reported minimal cardiovascular effects following administration of midazolam (the active ingredient contained in Versed)

Local

Local side effects at the site of injection (local flare reactions, pain, burning, phlebitis, local irritation and swelling) have been reported in up to 12% of patients. Vascular impairment after inadvertent intra-arterial injection is a theoretic concern.

Although local effects have been reported frequently, many clinicians believe that midazolam is the least likely of the commonly available injectable benzodiazepines to result in local reactions.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and hiccups have each been reported in about 3% of treated patients.

Nervous system

Nervous system side effects have included acute dystonia. One study (n=113) has reported that orally administered midazolam (the active ingredient contained in Versed) produced significant anterograde amnesia when administered as early as ten minutes before a surgical procedure.

Psychiatric

Psychiatric side effects have included a variety of adverse behavioral effects such as disinhibition (especially sexual disinhibition), hostility, rage reactions, restlessness, aggressiveness, and paroxysmal excitement.

Other

Other side effects including cases of benzodiazepine withdrawal symptoms (myalgias, tachycardia, and anxiety) have been reported in patients who have received multiple or continuous doses of midazolam (the active ingredient contained in Versed) In such patients, abrupt discontinuation is not recommended.

Immunologic

Immunologic side effects including pruritus, angioedema, and bronchoconstriction have been reported rarely.

Endocrine

Endocrine side effects have included decreases in the secretion of cortisol and insulin.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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