Versed Side Effects
Generic Name: midazolam
Note: This document contains side effect information about midazolam. Some of the dosage forms listed on this page may not apply to the brand name Versed.
Some side effects of Versed may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to midazolam: oral solution, oral syrup, oral tablet
Other dosage forms:
Along with its needed effects, midazolam (the active ingredient contained in Versed) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking midazolam:Less common
- chest pain or discomfort
- difficult or troubled breathing
- dry mouth
- fast heartbeat
- irregular heartbeats
- irregular, fast or slow, or shallow breathing
- lightheadedness, dizziness, or fainting
- noisy breathing
- pale or blue lips, fingernails, or skin
- shortness of breath
- slow or irregular heartbeat
- tightness in the chest
- trouble sleeping
- unable to speak
- unusual tiredness
- Attack, assault, or force
- changes in patterns and rhythms of speech
- feeling of constant movement of self or surroundings
- lack or loss of self-control
- loss of balance
- mood swings
- noisy breathing
- not breathing
- seeing, hearing, or feeling things that are not there
- sensation of spinning
- shakiness and unsteady walk
- slow to respond
- slurred speech
- trouble in speaking
- unsteadiness, trembling, or other problems with muscle control or coordination
Get emergency help immediately if any of the following symptoms of overdose occur while taking midazolam:Symptoms of overdose
- Change in consciousness
- difficulty with coordination
- loss of consciousness
- sleepiness or unusual drowsiness
Some side effects of midazolam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Blurred vision
- double vision
- seeing double
- watering of mouth and drooling
For Healthcare Professionals
Applies to midazolam: compounding powder, injectable solution, intravenous solution, oral syrup
Respiratory side effects, which have included cardiorespiratory depression, apnea, and respiratory arrest, are extensions of the drugs pharmacologic activity.
Personnel and equipment necessary for the treatment of respiratory depression and arrest should be immediately available whenever midazolam is administered.
One retrospective study has reported that the frequency of respiratory arrest (in nonventilated patients) is 0.099%. This study reported that respiratory arrest was associated with high doses of midazolam, concurrent administration of opioids, and advanced age.
Another study has reported that midazolam causes a decrease in tidal volume, an increase in breathing frequency and no change in minute ventilation in healthy volunteers. That study, however, did report a significant increase in CO2 retention following midazolam administration.
Cardiovascular side effects including alterations in blood pressure, arrhythmias, and ventricular irritability have been reported. Hypotension and decreases in systemic vascular resistance have been reported most frequently; however many investigators have reported minimal cardiovascular effects following administration of midazolam (the active ingredient contained in Versed)
Local side effects at the site of injection (local flare reactions, pain, burning, phlebitis, local irritation and swelling) have been reported in up to 12% of patients. Vascular impairment after inadvertent intra-arterial injection is a theoretic concern.
Although local effects have been reported frequently, many clinicians believe that midazolam is the least likely of the commonly available injectable benzodiazepines to result in local reactions.
Gastrointestinal side effects including nausea, vomiting, and hiccups have each been reported in about 3% of treated patients.
Nervous system side effects have included acute dystonia. One study (n=113) has reported that orally administered midazolam (the active ingredient contained in Versed) produced significant anterograde amnesia when administered as early as ten minutes before a surgical procedure.
Psychiatric side effects have included a variety of adverse behavioral effects such as disinhibition (especially sexual disinhibition), hostility, rage reactions, restlessness, aggressiveness, and paroxysmal excitement.
Other side effects including cases of benzodiazepine withdrawal symptoms (myalgias, tachycardia, and anxiety) have been reported in patients who have received multiple or continuous doses of midazolam (the active ingredient contained in Versed) In such patients, abrupt discontinuation is not recommended.
Immunologic side effects including pruritus, angioedema, and bronchoconstriction have been reported rarely.
Endocrine side effects have included decreases in the secretion of cortisol and insulin.
More about Versed (midazolam)
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