Midazolam Pregnancy and Breastfeeding Warnings
Midazolam is also known as: Versed
Midazolam Pregnancy Warnings
Midazolam has been assigned to pregnancy category D by the FDA. An increased risk of congenital malformations in humans has been suggested with use of other benzodiazepines. In addition, respiratory depression, decreased body temperature, decreased body tone and decreased arm recoil have been reported in the offspring of women who received midazolam before Cesarean section. Midazolam use is considered contraindicated during pregnancy.
The pharmacokinetic disposition of midazolam has been reported in pregnant women scheduled for elective Cesarean section. In such women, the volume of distribution averages 1.0 L/kg, the plasma clearance ranges from 11.5 to 13.9 mL/min/kg and the elimination half-life ranges from 0.8 to 1.7 hours. One report has suggested that, unlike women treated with diazepam, some women treated with midazolam as an adjuvant to regional anesthesia may not be able to recall the births of their babies.
Midazolam Breastfeeding Warnings
One small study has reported the pharmacokinetic data of five lactating women who underwent premedication with midazolam before induction of anesthesia. In 24 hours of milk collection, an average of 0.005% (0.002% to 0.013%) of the maternal midazolam was collected in the milk representing an average of 0.009% of the elimination clearance of the drug. The author of the study concluded that the amount of midazolam excreted into the milk within 24 hours of induction of anesthesia provided insufficient justification to interrupt breast-feeding.
Midazolam is excreted into human milk in very small amounts. Sedation is a theoretic concern but has not been reported. Midazolam is described by the American Academy of Pediatrics as a drug "whose effect on nursing infants is unknown but may be of concern".
- Midazolam use while Breastfeeding (in more detail)
- midazolam Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.