Trihexane Side Effects
Generic name: trihexyphenidyl
Note: This document contains side effect information about trihexyphenidyl. Some of the dosage forms listed on this page may not apply to the brand name Trihexane.
Some side effects of Trihexane may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to trihexyphenidyl: oral elixir, oral tablet
If you experience any of the following serious side effects, stop taking trihexyphenidyl (the active ingredient contained in Trihexane) and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
fast or irregular heartbeats;
anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;
eye pain; or
Other, less serious side effects may be more likely to occur. Continue to take trihexyphenidyl and talk to your doctor if you experience
dryness of the mouth;
large pupils or blurred vision;
drowsiness or dizziness;
difficulty urinating or constipation;
nervousness or anxiety;
upset stomach; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to trihexyphenidyl: oral elixir, oral tablet
Most adverse effects of trihexyphenidyl (the active ingredient contained in Trihexane) are extensions of its pharmacologic activity and are anticholinergic in nature. Between 30% and 50% of all patients experience minor side effects (dry mouth, nausea, blurred vision, dizziness, nervousness). Elderly patients and those with underlying organic brain disease tend to be the most susceptible, especially to the central effects.
Gastrointestinal side effects have included dry mouth, difficulty swallowing, anorexia, constipation, nausea, and vomiting. A reduction in dosage will sometimes help alleviate these problems. Paralytic ileus may develop, particularly in patients on concomitant phenothiazine or tricyclic antidepressant therapy, and may occasionally be fatal. Upon withdrawal of medication, nausea and vomiting may occur due to a cholinergic rebound.
Bucco-linguo-masticatory dyskinesias and chorea have been reported mostly in elderly patients being treated for Parkinson's disease with various anticholinergic agents, including trihexyphenidyl (the active ingredient contained in Trihexane)
Nervous system side effects have included depression, anxiety, listlessness, drowsiness, numbness of fingers and dyskinesia. Chorea has been reported at higher dosages (>=15 mg/day). Trihexyphenidyl may also aggravate symptoms of tardive dyskinesia or elicit previously suppressed symptoms. Sleepwalking has been attributed to drugs or combination of drugs with anticholinergic activity.
Cognitive deficits, such as impairment of recent and short-term memory and inability to concentrate, may occur with clinical doses of anticholinergic agents and may be dose-related.
Psychiatric side effects have included toxic psychosis which manifested as confusion, disorientation, agitation, excitation, memory impairment, delusions and hallucinations (usually visual, but may be auditory or tactile or all three), at toxic and therapeutic dosages (2% to 4%, up to 19% in elderly patients). Psychiatric deterioration and psychotic flare-ups have also been reported following withdrawal of therapy. Symptoms include delusions, hallucinations, aggression or violent behavior, and suicidal tendencies. In high dosages, trihexyphenidyl (the active ingredient contained in Trihexane) may sometimes produce euphorigenic effects. For this reason, it can be a drug of abuse.
Toxic psychosis, when present, tends to occur quickly, generally within several days to a week of initiating trihexyphenidyl therapy or within hours after an acute overdose. However, occasionally the onset may be delayed by months. Symptoms generally resolve spontaneously within a few days after the discontinuation of medication.
Ocular side effects have included blurred vision, mydriasis, and cycloplegia. Trihexyphenidyl (the active ingredient contained in Trihexane) may also cause angle-closure glaucoma, which has rarely led to blindness.
Cardiovascular side effects have included tachycardia, although an isolated case of bradycardia has also been described. Orthostatic hypotension has been reported during withdrawal syndromes following discontinuation of long-term trihexyphenidyl (the active ingredient contained in Trihexane) therapy.
Genitourinary side effects have included urinary retention and dysuria.
Metabolic side effects have included alterations in thermal homeostasis as a result of trihexyphenidyl (the active ingredient contained in Trihexane) s inhibition of the body's sweating mechanism. Heat stroke, hyperthermia, and fever have occurred with anticholinergic agents, most commonly in patients on concomitant neuroleptic or tricyclic antidepressant therapy.
Anticholinergic poisoning syndrome may persist for more than a week's duration following trihexyphenidyl (the active ingredient contained in Trihexane) overdose. Most patients with anticholinergic intoxication require only supportive therapy of vital functions and/or discontinuation of medications. However, severely agitated, delirious, or comatose patients may be treated with physostigmine salicylate, an acetylcholinesterase inhibitor with both central and peripheral effects.
Anticholinergic intoxication may present with central and peripheral symptoms including those listed above, in addition to warm and dry skin, EKG abnormalities, insomnia, twitching or jerking movements, pantomime activity with nonexistent objects, hyperactivity, hyperreflexia, respiratory arrest, delirium, convulsions, shock and coma.
More Trihexane resources
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.