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TL-Hist CM Side Effects

Generic Name: chlorpheniramine / codeine

Note: This page contains side effects data for the generic drug chlorpheniramine / codeine. It is possible that some of the dosage forms included below may not apply to the brand name TL-Hist CM.

It is possible that some side effects of TL-Hist CM may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to chlorpheniramine / codeine: liquid, tablets

Other dosage forms:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; thickening of mucus secretions; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / codeine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision, double vision, or other vision changes; confusion; difficulty urinating or inability to urinate; fast, slow, or irregular heartbeat; loss of coordination; mood or mental changes; nervousness; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; shallow breathing; tremor; trouble sleeping; uncontrolled muscle movements; unusual bruising or bleeding; unusual weakness or tiredness.

For Healthcare Professionals

Applies to chlorpheniramine / codeine: oral liquid, oral suspension, oral suspension extended release, oral tablet


Cardiovascular side effects have included fast, slow, or pounding heartbeat, hypertension, hypotension, orthostatic hypotension, palpitation, shock-like state, and syncope.[Ref]

Nervous system

Nervous system side effects have included blurred, double, or other visual disturbances; confusion; dizziness; depression; drowsiness and sedation; headache; euphoria; facial dyskinesia; false sense of well-being; feeling faint, lightheadedness, general feeling of discomfort or illness; nervousness, agitation and restlessness; minimal sedation; somnolence; insomnia, dyskinesia, irritability, and tremor.[Ref]


Gastrointestinal side effects have included abdominal distension, abdominal pain, acute pancreatitis, constipation, diarrhea, dry mouth, dyspepsia, epigastric distress, loss of appetite, nausea, vomiting, and decreased gastric motility with increased likelihood of esophageal reflux.[Ref]


Respiratory side effects have included dryness of pharynx and respiratory passages, laryngismus, nasal stuffiness, wheezing or troubled breathing, and respiratory depression.[Ref]


Endocrine side effects have included changes in glucose utilization, decreased lactation, early menses, glycosuria, gynecomastia, hypoglycemia, increased appetite, increased libido, and pheochromocytoma stimulation.[Ref]


Dermatologic side effects have included dermatitis, excessive perspiration, urticaria, erythema, pruritus, and rash.[Ref]


Hypersensitivity side effects have included allergic laryngospasm, atelectasis, bronchospastic allergic reaction, hives, itching, and swelling of face.[Ref]


Ocular side effects have included blurred vision, diplopia, hypermetropia, lacrimation increased, mydriasis, and photophobia.[Ref]


General side effects have included asthenia, feeling of relaxation, redness or flushing of the face, and unusual tiredness or weakness.[Ref]


Other side effects have included labyrinthitis, tinnitus, and vertigo.[Ref]


Immunologic side effects have included drug fever.[Ref]


1. "Product Information. Zodryl AC Adult (chlorpheniramine-codeine)." codaDOSE Incorporated, Flowery Branch [Atlanta], GA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.