Timentin Side Effects

Generic name: clavulanate / ticarcillin

Note: This document contains side effect information about clavulanate / ticarcillin. Some of the dosage forms listed on this page may not apply to the brand name Timentin.

Some side effects of Timentin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking clavulanate / ticarcillin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• blood in your urine, feeling an urgent need to urinate, painful or difficult urination;

• easy bruising or bleeding, unusual weakness;

• dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

• fever, chills, body aches, flu symptoms;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• chest pain; or

• seizure (convulsions).

Less serious side effects of clavulanate / ticarcillin may include:

• mild diarrhea, gas, stomach pain;

• nausea or vomiting;

• joint or muscle pain;

• headache;

• skin rash or itching;

• pain, swelling, or burning where the injection was given; or

• vaginal yeast infection (itching or discharge).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution

Gastrointestinal

Pseudomembranous colitis has been reported in patients treated with penicillins, and may occur during or after treatment. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.

Common (1% to 10%): Nausea (greater than or equal to 1%), diarrhea (greater than or equal to 1%)
Frequency not reported: Clostridium difficile associated diarrhea
Postmarketing reports: Taste and smell disturbances, stomatitis, flatulence, nausea, vomiting, diarrhea, epigastric pain, pseudomembranous colitis

Dermatologic

Common (1% to 10%): Rash (greater than or equal to 1%)
Postmarketing reports: Skin rash, pruritus, urticaria, bullous reactions (including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome)

Hematologic

The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.

Common (1% to 10%): Elevated eosinophils (greater than or equal to 3%)
Postmarketing reports: Thrombocytopenia, leukopenia, neutropenia, eosinophilia, decreased hemoglobin or hematocrit, prolonged prothrombin time and bleeding time

Hepatic

Common (1% to 10%): Elevated AST (greater than or equal to 3%), elevated ALT (greater than or equal to 3%)
Postmarketing reports: Elevated AST, elevated ALT, elevated serum alkaline phosphatase, elevated serum LDH, elevated serum bilirubin, transient hepatitis, cholestatic jaundice

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions (including skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, anaphylactic reactions, bullous reactions [including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome])

Metabolic

Frequency not reported: Hypokalemia
Postmarketing reports: Hypernatremia, decreased serum potassium, decreased uric acid

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.

Local

Common (1% to 10%): Phlebitis at the injection site (greater than or equal to 1%)
Postmarketing reports: Pain at the injection site, burning at the injection site, swelling at the injection site, induration at the injection site, thrombophlebitis with intravenous administration

Nervous system

Postmarketing reports: Headache, giddiness, neuromuscular hyperirritability, convulsive seizures

Genitourinary

Frequency not reported: Vaginal yeast infections
Postmarketing reports: Hemorrhagic cystitis

An increased incidence of vaginal yeast infections has been associated with penicillins.

Renal

Postmarketing reports: Elevated serum creatinine and/or BUN

Musculoskeletal

Postmarketing reports: Arthralgia, myalgia

Other

Postmarketing reports: Drug fever, chills, chest discomfort

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