Timentin Side Effects

Generic Name: clavulanate / ticarcillin

Note: This page contains side effects data for the generic drug clavulanate / ticarcillin. It is possible that some of the dosage forms included below may not apply to the brand name Timentin.

It is possible that some side effects of Timentin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to clavulanate / ticarcillin: intravenous powder for solution, intravenous solution

As well as its needed effects, clavulanate / ticarcillin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking clavulanate / ticarcillin, check with your doctor or nurse immediately:

Rare
  • Blood in the urine
  • frequent urination
  • lower abdominal or stomach cramping
  • painful urination
Incidence not known
  • Abdominal or stomach cramps, pain, or tenderness
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • changes in skin color
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • convulsions
  • cough
  • dark urine
  • diarrhea
  • diarrhea, watery and severe, which may also be bloody
  • dizziness
  • fast heartbeat
  • fever
  • general tiredness and weakness
  • headache
  • increased thirst
  • irritability
  • itching
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea or vomiting
  • pain, tenderness, or swelling of the foot or leg
  • pinpoint red spots on the skin
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling or inflammation of the mouth
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin

Some clavulanate / ticarcillin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste or bad unusual or unpleasant (after) taste
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • muscle aching, cramping, or stiffness
  • passing gas
  • swollen joints

For Healthcare Professionals

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution

Gastrointestinal

Pseudomembranous colitis has been reported in patients treated with penicillins, and may occur during or after treatment. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.

Common (1% to 10%): Nausea (greater than or equal to 1%), diarrhea (greater than or equal to 1%)
Frequency not reported: Clostridium difficile associated diarrhea
Postmarketing reports: Taste and smell disturbances, stomatitis, flatulence, nausea, vomiting, diarrhea, epigastric pain, pseudomembranous colitis

Dermatologic

Common (1% to 10%): Rash (greater than or equal to 1%)
Postmarketing reports: Skin rash, pruritus, urticaria, bullous reactions (including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome)

Hematologic

Common (1% to 10%): Elevated eosinophils (greater than or equal to 3%)
Postmarketing reports: Thrombocytopenia, leukopenia, neutropenia, eosinophilia, decreased hemoglobin or hematocrit, prolonged prothrombin time and bleeding time

The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.

Hepatic

Common (1% to 10%): Elevated AST (greater than or equal to 3%), elevated ALT (greater than or equal to 3%)
Postmarketing reports: Elevated AST, elevated ALT, elevated serum alkaline phosphatase, elevated serum LDH, elevated serum bilirubin, transient hepatitis, cholestatic jaundice

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions (including skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, anaphylactic reactions, bullous reactions [including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome])

Metabolic

Frequency not reported: Hypokalemia
Postmarketing reports: Hypernatremia, decreased serum potassium, decreased uric acid

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.

Local

Common (1% to 10%): Phlebitis at the injection site (greater than or equal to 1%)
Postmarketing reports: Pain at the injection site, burning at the injection site, swelling at the injection site, induration at the injection site, thrombophlebitis with intravenous administration

Nervous system

Postmarketing reports: Headache, giddiness, neuromuscular hyperirritability, convulsive seizures

Genitourinary

An increased incidence of vaginal yeast infections has been associated with penicillins.

Frequency not reported: Vaginal yeast infections
Postmarketing reports: Hemorrhagic cystitis

Renal

Postmarketing reports: Elevated serum creatinine and/or BUN

Musculoskeletal

Postmarketing reports: Arthralgia, myalgia

Other

Postmarketing reports: Drug fever, chills, chest discomfort

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