Skip to Content

Terazol Side Effects

Generic Name: terconazole topical

Note: This page contains side effects data for the generic drug terconazole topical. It is possible that some of the dosage forms included below may not apply to the brand name Terazol.

For the Consumer

Applies to terconazole topical: vaginal cream, vaginal suppository

As well as its needed effects, terconazole topical (the active ingredient contained in Terazol) may cause unwanted side effects that require medical attention.

Severity: Major

If any of the following side effects occur while taking terconazole topical, check with your doctor immediately:

More common
  • Burning feeling in the vagina
Less common
  • Chills
  • fever
  • itching or irritation in the vagina
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • cough
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives or welts
  • hoarseness
  • irritation
  • itching
  • joint or muscle pain
  • joint pain, stiffness or swelling
  • loss of appetite
  • muscle aches and pains
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • runny nose
  • shivering
  • skin rash
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting

Severity: Minor

Some terconazole topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Cramps
  • headache
  • heavy bleeding
  • pain
Less common
  • Abdominal or stomach pain
  • body pain
Incidence not known
  • Difficulty with moving
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pain or stiffness
  • swollen joints

For Healthcare Professionals

Applies to terconazole topical: vaginal cream, vaginal suppository

Nervous system

Very common (10% or more): Headache (up to 30.3%)
Postmarketing reports: Dizziness[Ref]

Headache was reported in 26%, 21%, and 30.3% of patients using the 0.4% vaginal cream, 0.8% vaginal cream, and vaginal suppositories, respectively. In clinical trials with the suppository, headache occurred in up to 20.7% of patients given placebo.[Ref]

Local

The suppository formulation was discontinued most often due to burning and pruritus.[Ref]

Frequency nor reported: Pain, rash

Vaginal suppositories:
-Very common (10% or more): Burning (15.2%)
-Common (1% to 10%): Pruritus[Ref]

Genitourinary

The cream formulations were discontinued most often due to vulvovaginal itching.[Ref]

Vaginal cream 0.4%:
-Frequency not reported: Vulvovaginal burning/itching/irritation

Vaginal cream 0.8%:
-Common (1% to 10%): Dysmenorrhea, genital burning and itching
-Frequency not reported: Vulvovaginal itching

Vaginal suppositories:
-Common (1% to 10%): Pain of the female genitalia[Ref]

Other

Frequency not reported: Influenza-like illness (consisting of fever, chills, nausea, dizziness)
Postmarketing reports: Asthenia, influenza-like illness (consisting of multiple reactions including fever, chills, nausea, vomiting, myalgia, arthralgia, malaise), face edema

Vaginal cream 0.4%
-Common (1% to 10%): Body pain, fever
-Uncommon (0.1% to 1%): Chills

Vaginal cream 0.8%
-Uncommon (0.1% to 1%): Fever

Vaginal suppositories
-Common (1% to 10%): Body pain, fever, chills[Ref]

Gastrointestinal

Vaginal cream 0.8%:
-Common (1% to 10%): Abdominal pain[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity, anaphylaxis[Ref]

Dermatologic

Photosensitivity reactions were reported after repeated dermal application of 2% and 0.8% cream formulations under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with the suppositories or vaginal cream (0.4% and 0.8%).[Ref]

Frequency not reported: Photosensitivity reactions
Postmarketing reports: Rash, toxic epidermal necrolysis, urticaria[Ref]

Respiratory

Frequency not reported: Dyspnea
Postmarketing reports: Bronchospasm[Ref]

At least 1 patient developed leukocytosis and dyspnea.[Ref]

Hematologic

At least 1 patient developed leukocytosis and dyspnea.[Ref]

Frequency not reported: Leukocytosis[Ref]

References

1. "Product Information. Terazol 3 (terconazole)." Ortho Pharmaceutical Corporation, Raritan, NJ.

It is possible that some side effects of Terazol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Terazol (terconazole topical)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide