Streptozocin Side Effects

Some side effects of streptozocin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to streptozocin: intravenous powder for solution

Along with their needed effects, medicines like streptozocin can sometimes cause unwanted effects such as kidney problems and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Streptozocin has been shown to cause tumors (some cancerous) in animals. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking streptozocin:

Less common
  • Anxiety, nervousness, or shakiness
  • chills, cold sweats, or cool, pale skin
  • drowsiness or unusual tiredness or weakness
  • fast pulse
  • headache
  • pain or redness at place of injection
  • unusual hunger

Check with your doctor immediately if any of the following side effects occur while taking streptozocin:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur while taking streptozocin:

More common
  • Swelling of feet or lower legs
  • unusual decrease in urination

Some side effects of streptozocin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Nausea and vomiting (usually occurs within 2 to 4 hours after receiving dose and may be severe)
Less common
  • Diarrhea

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

More common
  • Decrease in urination
  • swelling of feet or lower legs

For Healthcare Professionals

Applies to streptozocin: intravenous powder for injection


Renal toxicity is dose-related and cumulative. Adequate hydration may help reduce the risk of nephrotoxicity to renal tubular epithelium by decreasing renal and urinary concentration of the drug and its metabolites.

Renal side effects have included severe and sometimes fatal renal toxicity, azotemia, anuria, hypophosphatemia, glycosuria, and renal tubular acidosis. A case of chronic renal failure has also been reported.


Hematologic side effects have included fatal hematologic toxicity with substantial reductions in leukocyte and platelet counts. In most cases, hematologic toxicity only involves mild decreases in hematocrit values.


Severe nausea and vomiting have occasionally required the discontinuation of therapy.

Gastrointestinal side effects have included severe nausea and vomiting. Diarrhea has also been reported.


Abnormalities of glucose tolerance have generally been reversible.

Metabolic side effects have included mild to moderate abnormalities of glucose tolerance. Insulin shock with hypoglycemia has also been reported.


In most cases, local effects have been reported to resolve either the same day or within a few days.

Local side effects following extravasation have included erythema, burning, and tenderness.


Hepatic side effects have included hypoalbuminemia and elevated SGOT and LDH levels.


Genitourinary side effects have included two cases of nephrogenic diabetes insipidus.

One case of nephrogenic diabetes insipidus was reported to have had a spontaneous recovery while the second case responded to indomethacin.

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