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Streptozocin Side Effects

For the Consumer

Applies to streptozocin: intravenous powder for solution

Along with their needed effects, medicines like streptozocin can sometimes cause unwanted effects such as kidney problems and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Streptozocin has been shown to cause tumors (some cancerous) in animals. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Severity: Major

If any of the following side effects occur while taking streptozocin, check with your doctor immediately:

Less common:
  • Anxiety, nervousness, or shakiness
  • chills, cold sweats, or cool, pale skin
  • drowsiness or unusual tiredness or weakness
  • fast pulse
  • headache
  • pain or redness at place of injection
  • unusual hunger

Severity: Major

If any of the following side effects occur while taking streptozocin, check with your doctor immediately:

Rare:
  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Severity: Moderate

If any of the following side effects occur while taking streptozocin, check with your doctor or nurse as soon as possible:

More common:
  • Swelling of feet or lower legs
  • unusual decrease in urination

Severity: Minor

Some streptozocin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Nausea and vomiting (usually occurs within 2 to 4 hours after receiving dose and may be severe)
Less common:
  • Diarrhea

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

More common:
  • Decrease in urination
  • swelling of feet or lower legs

For Healthcare Professionals

Applies to streptozocin: intravenous powder for injection

Renal

Frequency not reported: Renal toxicity (azotemia, anuria, hypophosphatemia, glycosuria, renal tubular acidosis), nephrogenic diabetes insipidus[Ref]

Hepatic

Frequency not reported: Hepatic toxicity (elevated SGOT and LDH levels, hypoalbuminemia)[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea[Ref]

Hematologic

Rare (less than 0.1%): Hematologic toxicity (decreased hematocrit values, reduced leukocyte and platelet count)[Ref]

Metabolic

Frequency not reported: Glucose tolerance abnormalities, insulin shock, hypoglycemia[Ref]

Local

Postmarketing reports: Local inflammation[Ref]

Psychiatric

Frequency not reported: Confusion, lethargy, depression[Ref]

References

1. "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn, Kalamazoo, MI.

It is possible that some side effects of streptozocin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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